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10 Genetic Disorders in Purebred vs. Mixed-Breed Dogs

Pet owners commonly assume that purebred dogs are more prone to inherited disorders and that mixed-breed dogs are healthier.  

Is this a fact or a myth?  
Research suggests that this distinction is not always so categorical.   

Are Mixed-Breed Dogs Healthier Than Purebred Dogs?

Pet owners of purebred dogs are given higher pet insurance premiums because their pets may need coverage for inherited disorders. However, the latest data shows that the generalization of purebreds as less healthy and more prone to inherited genetic disorders is not always true.   

One study investigated 10 genetic conditions and compared them to see whether mixed-breed or purebred had a higher chance of inheriting them.   

The most shocking finding was that most purebred subgroups are just as statistically likely to develop disorders as much as mixed breed dogs are for 7 genetic conditions.  

This disproves the common assumption that mixed breed dogs are healthier than purebreds.  

Purebreds are more likely to have only 3 out of the 10 examined genetic disorders. 

Purebred Dogs' Category

To better understand which dog breeds, have a higher prevalence of inheriting these conditions, they have been categorized into subgroups.  

The American Kennel Club has seven groups of dogs depending on the breed’s characteristics and functions the dogs were originally bred for.  

The groups and some popular breeds of that category are as follows:   

Conditions

Certain subgroups of purebred had a higher disposition for developing 

Purebred subpopulations do not differ statistically from mixed-breed dogs

Aortic stenosis

Atopy/allergic dermatitis  

Aortic stenosis

Skin allergies  

Hypothyroidism  

Bloat  

Bloat  

Intervertebral disk disease  

Early-onset cataracts  

Early-onset cataracts  

Dilated cardiomyopathy  

Dilated cardiomyopathy  

Elbow dysplasia   

Elbow dysplasia  

Epilepsy  

Epilepsy  

Portosystemic shunt  

Hypothyroidism  

Intervertebral disk disease  

Hepatic portosystemic shunt  

Inherited Conditions that Affect only Certain Subgroups of Purebred Dogs

Aortic stenosis

Aortic stenosis is a narrowing above the aortic heart valve or the aortic valve itself. It is statistically more common in working, sporting, and herding subgroups of dogs.   

Bloat

Stomach dilatation or bloat is a serious condition and can be fatal if left untreated. Non-sporting and working subgroups of dogs are significantly more affected by this disease.   

Early-onset cataracts

As the name suggests, this condition develops early in a dog’s life by clouding the lens inside the eye, causing blindness. Non-sporting and sporting subgroups of purebred dogs were found to have a greater probability of developing this condition.   

Dilated cardiomyopathy

This genetic condition creates enlargement of the chambers of the heart and thinning of the muscle wall. It typically affects large and giant-sized dogs of the hound, sporting, and working subgroup of dogs.   

Elbow dysplasia

Large breed dogs are most affected by an abnormal growth of tissues, leading to malformation and degeneration of the joint. Herding, sporting, and working subgroups, especially Golden retrievers, the Newfoundland, German shepherds, Bernese Mountain Dogs, and Rottweilers, are all known to be predisposed to elbow dysplasia.   

Epilepsy

Repeated brain seizures are one of the most frequently reported neurological disorders in dogs. In most cases, epilepsy cannot be cured. Herding, hound, and sporting are more prone to developing epilepsy.   

Hepatic portosystemic shunt

Terrier and toy grouping have an increased incidence of a portosystemic shunt. This condition is an abnormal connection where blood is diverted around the liver rather than into it. Surgery is often needed to treat and correct the shunt.   

Inherited Conditions with Higher Prevalence among most Purebred Dogs

Skin allergies

Atopy or allergic dermatitis is a condition that is dogs suffer from frequently depending on environmental circumstances or genetics.   

Hypothyroidism

The underactive production of thyroid hormones can affect a dog’s quality of life in many ways. This disease is not life-threatening and inexpensive to treat.  

Intervertebral disk disease

IVDD causes problems with the disks between the vertebrae of the spine leading to neurological issues. This degenerative process can affect the dog’s ability to walk and often requires surgical intervention.  

It is interesting to note that although the risk is increased for most subgroups of developing this condition, the terrier subgroup has reduced risk compared to mixed-breed dogs.   

Hound

Working

Sporting

Non-Sporting

Terrier

Toy

Herding

Aortic stenosis

Increased  
Risk  

Increased  
Risk  

Increased  
Risk  

Bloat  

Increased  
Risk  

Increased  
Risk  

Early-onset cataracts  

Increased  
Risk  

Increased  
Risk  

Dilated cardiomyopathy  

Increased  
Risk  

Increased  
Risk  

Increased  
Risk  

Elbow dysplasia  

Increased  
Risk  

Increased  
Risk  

Increased  
Risk  

Epilepsy  

Increased  
Risk  

Increased  
Risk  

Increased  
Risk  

Hepatic portosystemic shunt  

Increased  
Risk  

Increased  
Risk  

Skin allergies  

Increased  
Risk  

Increased  
Risk  

Increased  
Risk  

Increased  
Risk  

Hypothy-
roidism
  

Increased  
Risk  

Increased  
Risk  

Increased  
Risk  

Increased  
Risk  

Intervertebral disk disease  

Increased  
Risk  

Increased  
Risk  

Increased  
Risk  

Reduced
Risk  

Increased  
Risk  

Empty cells mean the risk is not statistically distinct from a mixed breed developing the same condition.  

Pet owners need to be aware of the health risks and conditions their pet is predisposed to develop. Early screenings and responsible breeding are just some ways pet owners can reduce the prevalence of these conditions among the dog population.  

Hence, the common assumption that purebred dogs are unhealthier than mixed breed is not always true.